WebJan 15, 2016 · There is much interest in using the Hochberg procedure (HP) for statistical tests on primary endpoints of confirmatory clinical trials. The procedure is simple to use … WebMar 23, 2024 · Using the function numPairDeColNames() we can easily extract the UPS1 concentrations as numeric content and show the (log-)ratio of the pairwise comparisons (column ‘log2rat’), the final concentrations (columns ‘conc1’ and ‘conc2’, in amol) and the number of differentially abundant proteins passing 5% FDR (using classical Benjamini …

Truncated Product Method for Combining p-values

WebMay 18, 2024 · A truncated Hochberg procedure was used to test the primary end points. Given that both primary end points were met, an alpha of .05 was passed to OS. A Haybittle-Peto rule was used to adjust the alpha for analyses of OS at two time points. WebHochberg’s (1988) procedure is widely used in practice because of its simple step-up testing algorithm and higher power in the class of p-value-based multiple test procedures, … irons hawk logo

Gatekeeping Procedures in Clinical Trials Request PDF

WebEach of the two primary hypotheses were tested individually at alpha equal to 0.025. The two key secondary end points were tested using a step-up Hochberg procedure outlined as follows. Initially, the primary hypotheses were tested under a truncated Hochberg procedure with a truncation parameter of 0, which reduced to Bonferroni. WebThe same procedure will be applied to H 2, H 5, and H 6. If one wishes to use a more powerful method such as Hochberg, it can be done for the second family among H 3 and H 4 (or H 5 and H 6). Instead of equally splitting α/2 between H 3 and H 4, one can compare the larger p-value of H 3 and H 4 with α/2 and reject both of the hypotheses if p ... WebThis section describes another two-stage procedure derived by Hochberg (1975).In contrast to Tamhane's procedure, Hochberg's method allows the possibility of no additional … port wentworth senior center