WebGene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes. ... High expression of THBS2 and TAGLN in MOC confers an adverse prognosis and is upregulated in the infiltrative subtype, which warrants further investigation. ... Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of th…
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WebTHBS2 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, THBS2 Genome Browser, THBS2 References. THBS2 - Explore an overview of THBS2, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. Web10 Jun 2008 · HGNC Approved Gene Symbol: THBS2 Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:169,215,785-169,253,846 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Cloning and Expression Thrombospondin was originally discovered as a secretory product of platelet alpha-granules ( Baenziger et al., …
Web21 Mar 2024 · TNXB (Tenascin XB) is a Protein Coding gene. Diseases associated with TNXB include Ehlers-Danlos Syndrome, Classic-Like and Vesicoureteral Reflux 8 . Among its related pathways are PI3K-Akt signaling pathway and Extracellular matrix organization . Gene Ontology (GO) annotations related to this gene include heparin binding and collagen … Web22 Jan 2024 · Thbs2 thrombospondin 2 [ (house mouse)] Gene ID: 21826, updated on 22-Jan-2024 Summary Predicted to enable calcium ion binding activity and heparin binding …
Web10 Sep 2024 · We identified gene expression clusters that strongly correlate with fibrosis stage including four genes that have been found consistently across previously published transcriptomic studies on... WebIdentifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis Xian-guo Zhou,1,2,* Xiao-liang Huang,1,2,* Si-yuan Liang,1–3 Shao-mei Tang,1,2 Si-kao Wu,1,2 Tong-tong Huang,1,2 Zeng-nan Mo,1,2,4 Qiu-yan Wang1,2,5 1Center for Genomic and Personalized Medicine, Guangxi Medical …
Web1 Jan 2006 · The THBS2 gene is 38,261 bases in size and is composed of 23 exons. Exons 3-22 encode the 5,808 base mRNA. Transcription. Unlike TSP1, TSP2 is less-to-moderately responsive to serum in mouse NIH3T3 and Swiss 3T3 cells respectively. Transcription of THBS2 in some human cancers is suppressed through hypermethylation.
http://www.cancerindex.org/geneweb/THBS2.htm cnn winter solsticeWebTHBS2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. cal berkeley average gpaWebGene target information for THBS2 - thrombospondin 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. cnn wi resultsWebResults Based on bioinformatics analyses, THBS2 (FC: 7.14, FDR < 0.0001) has a significantly high expression in GC samples. lncRNAs BAIAP2-AS1, TSIX, and LINC01215 have RNA interaction with THBS2. cnn wisconsin election results 2022WebTHBS2; thrombospondin 2. Aliases: TSP2. Location: 6q27. Summary: The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric … cnn winter olympics 2022Web8 Jan 2024 · CytoHubba selected the top ten hub genes, which included SPP1, TIMP1, SERPINE1, MMP3, COL1A1, BGN, THBS2, CDH2, CXCL8, and THY1. With the exception of SPP1, survival analysis using the Kaplan–Meier database showed that the levels of expression of these genes were associated with overall survival. cnn wiredWebTSP1 (mouse gene, Thbs1) and TSP2 (Thbs2) have both been disrupted in mice and have unique phenotypes associated with each gene. Thbs1 is a regulator of TGF-β in vivo, and these null animals have lower viability and prolonged wound healing. For skeletal phenotypes, this model has spine curvature and craniofacial alterations. cal berkeley banner