Phenylephrine and cardiac output
Web13. mar 2024 · Compared to phenylephrine, norepinephrine has a shorter half-life (2 - 3 minutes) and improves the MAP by increase in cardiac contractility. In a recent study at our department it was demonstrated that besides arterial vasoconstriction, phenylephrine also improves venous return and cardiac output by venous vasoconstriction. Web22. aug 2008 · In contrast to the beneficial effects of vasodilator drugs, the administration of strong vasopressors may decrease cardiac output by increasing afterload, even in individuals with normal cardiac function. This effect is seen, for example, with phenylephrine, which has almost pure α-adrenergic effects.
Phenylephrine and cardiac output
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WebPhenylephrine with its appealing α agonist property proved to be a valid vasopressor for correction of hypotension during SA but with side effects like reflex bradycardia and fall in cardiac output. Noradrenaline is a rational substitute to phenylephrine due to its mild β and prominent α adrenergic properties, but is reserved as an inotrope ... Web22. mar 2024 · As a pure α-agonist, phenylephrine is conventionally considered to solely induce arterial vasoconstriction and thus increase cardiac afterload but not cardiac preload. In specific circumstances, however, phenylephrine may also contribute to an increase in venous return and thus cardiac output (CO).
Web1. máj 2024 · Phenylephrine and cardiac output Article May 2024 Simon Gelman Reuven Pizov View The Impact of Phenylephrine, Ephedrine, and Increased Preload on Third … Web26. jan 2012 · There are two main mechanisms by which phenylephrine could alter cardiac output: the first is that phenylephrine raises ventricular afterload and thereby decreases …
Web1. máj 2024 · Although phenylephrine is widely used in the operating room to control arterial pressure, its haemodynamic effects remain controversial. Objective: We hypothesised … Web10. apr 2024 · Phenylephrine is a selective α1-adrenergic receptor agonist that has been used to induce vasoconstriction and increased blood pressure for evaluation of blood pressure and other cardiac performance measurement devices [ 18, 19 ].
Web11. júl 2024 · Although phenylephrine is not recommended as the initial treatment of septic shock, it is an acceptable therapy in the case of norepinephrine associated arrhythmias, known high cardiac output with hypotension, and as a salvage therapy when combined inotrope and vasopressor drugs when low-dose vasopressin has failed to achieve MAP …
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